Survey looks at why patients request stem cell treatments


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In one of many first research of its sort, Mayo Clinic researchers have analyzed a big group of sufferers to grasp their motivations for in search of stem cell therapies and whether or not expectations are grounded in science. The findings may assist well being care professionals minimize by way of deceptive claims and higher counsel sufferers. The analysis by Jennifer Arthurs; Zubin Grasp, Ph.D.; and Shane Shapiro, M.D., is revealed in npj Regenerative Medication.
“We discovered that many sufferers excited about stem had beliefs that aren’t supported by present medical proof. For instance, many thought had been higher than surgical procedure or the usual of care,” says co-author senior Dr. Grasp, a bioethicist in Mayo Clinic’s Middle for Regenerative Medication in Rochester.
The analysis group analyzed 533 individuals, the most important identified sampling of sufferers in search of stem cell and different regenerative therapies for musculoskeletal circumstances, therapies often called orthobiologics. The sufferers surveyed had been contemplating a session at Mayo Clinic’s Regenerative Medication Therapeutic Suites between November 2018 and February 2020. They’d a median age of 68, and half had been girls.
They had been requested three questions:
Why are you interested by stem cell remedy on your situation?How did you discover out about stem cell remedy on your situation?Have you ever contacted a stem cell clinic?
Roughly 27% stated they thought would delay or keep away from joint substitute surgical procedure; 26% stated they thought it might ease ache; and practically 19% thought stem cell injections can be a greater or much less invasive possibility than surgical procedure.
“Scientific proof doesn’t recommend that joint substitute or tendon restore is totally avoidable or that stem cell remedy is best than commonplace of care or surgical choices,” says co-senior creator Dr. Shapiro, medical director of the Regenerative Medication Therapeutic Suites at Mayo Clinic in Jacksonville, Florida.
The commonest supply of knowledge respondents cited was on-line web searches, adopted by word-of-mouth suggestion from household or pals.
“Understanding sufferers’ well being data and intentions when contemplating orthobiologics and stem cell remedy is essential to assist sufferers navigate the varied scientific choices acceptable for his or her care wants,” says Arthurs.
The evaluation revealed that lots of the sufferers had contacted a stem cell clinic earlier than in search of session at Mayo Clinic. Nonetheless, those that had been keen to have an in-person session had been much less prone to have contacted a stem cell clinic and extra prone to have been referred to Mayo by a well being care skilled.
Most shocking to the analysis group is that many sufferers had not heard about stem cell procedures from the ClinicalTrials.gov web site, the place stem cell clinics typically current their companies as pay-to-participate experimental analysis.
“Our information recommend that insurance policies to extend oversight of the ClinicalTrials.gov website might not serve to really inform sufferers that a few of the listed research within the registry are usually not precise analysis research however are deceptive claims by stem cell clinics,” says Dr. Grasp.
The research group concludes that well being care professionals excited about advancing accountable stem cell and orthobiologic therapies ought to seek the advice of with sufferers on their totally different choices, present factual info and proper misunderstandings whereas respecting affected person motivations for in search of such therapies.
As a result of this analysis is especially amongst sufferers in search of stem cell therapies for musculoskeletal circumstances, the group recommends additional research to replicate the attitudes of a wider inhabitants excited about orthobiologic and stem cell therapies.

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Extra info:
Jennifer R. Arthurs et al, Sufferers in search of stem cell therapies—a potential qualitative evaluation from a Regenerative Medication Seek the advice of Service, npj Regenerative Medication (2022). DOI: 10.1038/s41536-022-00215-w

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Survey appears at why sufferers request stem cell remedies (2022, July 19)
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