Ringworm Uses, Warnings, Side Effects, Dosage


Generic Identify: griseofulvin

Model Names: Gris-PEG, Grifulvin V (discontinued model)

Drug Class: Antifungals, Systemic

What’s griseofulvin, and what’s it used for?

Griseofulvin is an antibiotic derived from Penicillium species of fungi used to deal with ringworm infections brought on by particular fungi species. Griseofulvin is a systemic drug used solely to deal with fungal infections which are refractory to topical antifungal therapies and never for minor infections.

The kind of fungi liable for the infections needs to be first recognized earlier than beginning griseofulvin remedy. Griseofulvin is efficient for infections from numerous species of Microsporum, Epidermophyton and Trichophyton, however has no impact on micro organism or different genera of fungi.

Griseofulvin prevents fungal development by inhibiting fungal DNA synthesis and cell division. Oral griseofulvin is absorbed systemically and is deposited in keratin, a sort of protein in epithelial cells that line the outer floor of the physique and the surfaces of inside organs. Keratin is present in pores and skin, nail, hair, and hair follicles. Griseofulvin binds with new keratin that varieties within the epithelial cells making it extremely proof against fungal development. The fungal an infection clears because the previous contaminated cells are shed and the resistant cells type the brand new pores and skin layer.

Griseofulvin is used within the therapy of the next fungal infections:

Griseofulvin has no results towards bacterial infections, candidiasis, tinea versicolor, and different sorts of fungal infections. Griseofulvin is lively towards solely the next species of fungi:

Trichophyton rubrum, Trichophyton tonsurans, Trichophyton mentagrophytes, Trichophyton interdigitalis,Trichophyton verrucosum, Trichophyton megnini, Trichophyton gallinae, Trichophyton crateriform, Trichophyton sulphureum, Trichophyton schoenleini, Microsporum audouini, Microsporum canis, Microsporum gypseum and Epidermophyton floccosum.

What are the negative effects of griseofulvin?

Frequent negative effects of griseofulvin embrace:

Much less widespread negative effects of griseofulvin embrace:

Impaired coordination
Peripheral nerve illness (neuropathy)
Loss of appetite (anorexia)
Gastrointestinal bleeding
Style sensation modifications

Uncommon negative effects of griseofulvin normally with excessive doses, lengthy therapy length or each:

Kidney dysfunction (nephrosis)
Extreme protein in the urine (proteinuria)
Liver toxicity
Improve in serum bilirubin
Improve in liver enzymes (transaminases)
Lowered rely of granulocyte immune cells in blood (granulocytopenia)
Lowered leukocyte immune cells in blood (leukopenia)
Low red blood cell count (anemia)
Numbness and tingling (paresthesia) of arms and feet
Swelling of tissue beneath the pores and skin and mucous membranes (angioneurotic edema)
Drug-induced lupus-like syndrome
Extreme pores and skin reactions together with:

Stevens-Johnson syndrome
Poisonous epidermal necrosis

Menstrual irregularities

Name your physician instantly in the event you expertise any of the next signs or severe negative effects whereas utilizing this drug:

Severe heart symptoms embrace quick or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness;
Extreme headache, confusion, slurred speech, extreme weakness, vomiting, lack of coordination, feeling unsteady;
Extreme nervous system response with very stiff muscular tissues, excessive fever, sweating, confusion, quick or uneven heartbeats, tremors, and feeling such as you may go out; or
Severe eye signs embrace blurred vision, tunnel vision, eye pain or swelling, or seeing halos round lights.

This isn’t a whole record of all negative effects or hostile reactions which will happen from the usage of this drug. Name your physician for medical recommendation about severe negative effects or hostile reactions. You might also report negative effects or well being issues to the FDA at 1-800-FDA-1088.

What are the dosages of griseofulvin?

Oral suspension, microsize

Pill, microsize

Pill, ultramicrosize

125 mg (Gris-PEG)
250 mg (Gris-PEG)

Tinea An infection

Infections affecting pores and skin, physique, hair/beard, or nails

Grownup:

Microsize

Tinea corporis, cruris, or capitis: 500 mg/day orally
Tinea pedis or unguium: 1000 mg/day orally as a single every day dose or divided each 12 hours

Ultramicrosize

Tinea corporis, cruris, or capitis: 375 mg/day orally
Tinea pedis or unguium: 250 mg orally each 8 hours

Pediatric:

Youngsters beneath 2 years previous: security and efficacy not established

Microsize

11 mg/kg/day orally as a single dose or divided each 12 hours
Youngsters 13.6-22.7 kg (30-50 lb): 125-250 mg/day
Youngsters over 22.7 kg (over 50 lb): 250-500 mg/day
Off-label: 10-20 mg/kg/day divided each 12 hours

Extremely-micro-size

7.3 mg/kg/day orally
Youngsters 13.6-22.7 kg (3-50 lb): 82.5-165 mg/day
Youngsters over 22.7 kg (over 50 lb): 135-330 mg/day
Off-label: 5-15 mg/kg/day orally divided each 12 hours; to not exceed 750 mg/day

Remedy length

Depending on an infection web site
Tinea corporis: 2-4 weeks
Tinea capitalize: 4-6 weeks; perhaps as much as 8-12 weeks
Tinea pedis: 4-8 weeks
Tinea unguium: 4-6 months

Dosing issues:

Absorption elevated with fatty meals

IMAGES

Eczema
Browse our medical image collection of allergic skin disorders such as psoriasis and dermatitis and more caused by allergies
See Images

Overdose

There are not any recognized experiences of griseofulvin overdose. Overdose signs might embrace nausea, vomiting, headache, pores and skin eruptions, numbness and tingling, vertigo and confusion.
There isn’t a particular antidote for griseofulvin and overdose is handled with symptomatic and supportive care. Undigested drug within the abdomen could also be eradicated with induced vomiting or gastric lavage and activated charcoal administration.

What medicine work together with griseofulvin?

Inform your physician of all drugs you’re at present taking, who can advise you on any potential drug interactions. By no means start taking, out of the blue discontinue, or change the dosage of any remedy with out your physician’s advice.

Griseofulvin has no recognized extreme interactions with different drugs.
Griseofulvin has severe interactions with 23 completely different medicine.
Griseofulvin has average interactions with 112 completely different medicine.
Griseofulvin has minor interactions with 61 completely different medicine.

The drug interactions listed above are usually not the entire potential interactions or hostile results. For extra info on drug interactions, go to the RxList Drug Interplay Checker.

It is very important at all times inform your physician, pharmacist, or well being care supplier of all prescription and over-the-counter drugs you utilize, in addition to the dosage for every, and hold an inventory of the knowledge. Test along with your physician or well being care supplier in case you have any questions concerning the remedy.

Subscribe to MedicineNet’s Pores and skin Care & Situations E-newsletter

By clicking “Submit,” I comply with the MedicineNet Terms and Conditions and Privacy Policy. I additionally comply with obtain emails from MedicineNet and I perceive that I could choose out of MedicineNet subscriptions at any time.

Being pregnant and breastfeeding

Don’t use griseofulvin throughout pregnancy. Animal research present proof of fetal hurt with griseofulvin use throughout being pregnant. There are experiences of conjoined twins in two pregnant girls who took griseofulvin within the first trimester of being pregnant.
Girls of being pregnant potential should use efficient contraception throughout griseofulvin remedy and for no less than a month after completion of therapy.
Animal research present griseofulvin could cause chromosomal aberrations in males. Males ought to observe efficient contraception throughout remedy and for six months after completion of therapy.
It’s not recognized if griseofulvin is excreted in breast milk. Keep away from use in nursing moms.

What else ought to I learn about griseofulvin?

Take griseofulvin precisely as prescribed. Take with a fatty meal to enhance drug absorption and forestall gastrointestinal upset.
Test along with your healthcare supplier for periodic assessments in case you are on extended remedy.
Keep away from publicity to intense daylight whereas on griseofulvin remedy, it could trigger photosensitive reactions.
Keep away from ingesting alcohol whereas on griseofulvin remedy, it could potentiate alcohol results, inflicting signs reminiscent of fast heartbeat (tachycardia) and flushing.
Retailer griseofulvin fastidiously out of attain of kids.
In case of unintended overdose, search medical assist instantly or contact Poison Control.

From WebMD Logo

Pores and skin Issues and Therapies Sources

Well being Options From Our Sponsors

Medically Reviewed on 7/14/2022
References

REFERENCES:
https://www.rxlist.com/consumer_griseofulvin_gris-peg/drugs-condition.htm
https://reference.medscape.com/drug/grifulvin-v-gris-peg-griseofulvin-342590#0
https://www.uptodate.com/contents/griseofulvin-drug-information
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050475s057lbl.pdf
https://www.medicines.org.uk/emc/product/10746/smpc#gref
https://www.ncbi.nlm.nih.gov/books/NBK537323/