Lipitor Statin (Atorvastatin) Side Effects, Uses, & Dosage

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What’s Lipitor (atorvastatin), and what’s it used for?

Model identify: Lipitor
Generic identify: atorvastatin
Dosage varieties: pill (10 mg)
Drug class: statins, HMG-CoA reductase inhibitors, lipid-lowering brokers

Lipitor (atorvastatin) is kind of statin that lowers the extent of cholesterol within the blood. All statins, together with atorvastatin, stop the manufacturing of ldl cholesterol within the liver by blocking HMG-CoA reductase, an enzyme that makes ldl cholesterol. Statins scale back whole ldl cholesterol in addition to LDL cholesterol in blood.

LDL cholesterol is believed to be the “dangerous” ldl cholesterol that’s primarily answerable for the event of coronary artery disease. Decreasing LDL cholesterol levels retards development and should even reverse coronary artery disease. Atorvastatin additionally raises the concentrations of HDL (“good”) ldl cholesterol that protects in opposition to coronary artery illness and reduces the focus of triglycerides within the blood. (Excessive blood concentrations of triglycerides even have been related to coronary artery illness.)

Examples of different statins embody:

Lipitor (atorvastatin) makes use of

Lipitor is used for the therapy of elevated whole ldl cholesterol, LDL, and triglycerides, and to raise HDL cholesterol. The effectiveness of Lipitor in lowering cholesterol is dose-related, which means that increased doses scale back ldl cholesterol extra.

In people with coronary artery illness Lipitor prevents:

Lipitor reduces the chance of heart assault, stroke, angina, and revascularization procedures in adults with out proof of coronary heart disease, however with a number of danger components for coronary artery illness, for instance:

What are the unwanted effects of atorvastatin?

Lipitor (atorvastatin) is usually effectively tolerated. Minor unwanted effects embody:

Different generally reported unwanted effects embody:

Lipitor might trigger liver and muscle injury. Critical liver injury attributable to statins is uncommon. Liver tests must be carried out at first of therapy then as wanted thereafter.

Irritation of the muscle mass attributable to statins can result in critical breakdown of muscle cells known as rhabdomyolysis. Rhabdomyolysis causes the discharge of muscle protein (myoglobin) into the blood, and myoglobin may cause kidney failure and even demise. When used alone, statins trigger rhabdomyolysis in lower than one p.c of sufferers. To stop the event of great rhabdomyolysis, sufferers taking atorvastatin ought to contact their health-care skilled instantly in the event that they develop unexplained muscle pain, weakness, or muscle tenderness.

Statins have been related to will increase in HbA1c and fasting serum glucose ranges as seen in diabetes.

Publish-marketing stories for atorvastatin of adversarial occasions embody:

Signs might begin sooner or later to years after beginning therapy and resolve inside a median of three weeks after stopping the statin.

What’s the dosage for atorvastatin?

Lipitor is prescribed as soon as every day.
The standard beginning dose for adults is 10-20 mg per day, and the utmost dose is 80 mg per day. Adults who want greater than a forty five% discount in LDL cholesterol could also be began at 40 mg every day.
Pediatric sufferers ought to obtain 10 mg as soon as every day as much as a most dose of 20 mg every day.
Lipitor could also be taken with or with out meals and at any time of day.

SLIDESHOW

How to Lower Your Cholesterol & Save Your Heart
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What medication work together with atorvastatin?

Decreased elimination of Lipitor may enhance ranges of Lipitor within the physique and enhance the chance of muscle toxicity from Lipitor. Subsequently, Lipitor shouldn’t be mixed with drugs that lower its elimination. Examples of such medication contains:

Giant portions of grape fruit juice (>1.2 liters every day) additionally will enhance blood ranges of Lipitor and shouldn’t be taken.

The next medication additionally might enhance the chance of muscle toxicity when mixed with Lipitor.

Lipitor will increase the impact of warfarin and the focus in blood of digoxin (Lanoxin). Sufferers taking Lipitor and warfarin or digoxin must be monitored rigorously. Cholestyramine decreases the absorption of Lipitor. Lipitor must be given at the very least two hours earlier than and at the very least 4 hours after cholestyramine.

Rifampin will increase breakdown of Lipitor. To scale back the probability of this interplay each medication must be given on the identical time. Lipitor shouldn’t be given after rifampin.

Is atorvastatin protected to make use of throughout being pregnant or whereas breastfeeding?

Lipitor might trigger fetal hurt when administered to a pregnant lady. Lipitor must be discontinued as quickly as pregnancy is acknowledged. Lipitor ought to solely be administered to ladies of childbearing age if they aren’t prone to turn into pregnant.
It isn’t identified if Lipitor is secreted in breast milk. Due to the potential danger of adversarial occasions, breastfeeding moms mustn’t use Lipitor.

Medically Reviewed on 12/8/2021
References

FDA Prescribing Info

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