Early Menopause May Raise a Woman’s Odds for Dementia

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TUESDAY, March 1, 2022 (HealthDay Information) — Ladies who enter menopause early could also be extra more likely to develop dementia later in life, new analysis signifies.

Throughout menopause, manufacturing of the feminine intercourse hormone estrogen drops dramatically and a girl’s intervals come to an finish. Whereas girls usually enter menopause of their early 50s, many accomplish that earlier — both naturally or resulting from a medical situation or therapy akin to a hysterectomy (removing of the uterus).

This huge research discovered that girls within the U.Ok. who entered menopause earlier than age 40 have been 35% extra more likely to develop dementia later in life than girls who began menopause round age 50.

What’s extra, girls who entered menopause earlier than age 45 have been 1.3 occasions extra more likely to develop dementia earlier than their sixty fifth birthday, the brand new research confirmed.

“Ladies with early menopause might have a detailed monitoring of their cognitive decline in scientific apply,” stated research writer Dr. Wenting Hao, a Ph.D. candidate at Shandong College in Jinan, China.

The upper threat for dementia could also be because of the sharp estrogen drop that takes place throughout menopause, Hao stated.

“Estrogen can activate mobile antioxidants akin to glutathione, cut back ApoE4, the commonest genetic threat issue within the pathogenesis of dementia, and cut back amyloid plaque deposition within the mind,” she defined.

The build-up of amyloid plaques within the mind is among the hallmarks of Alzheimer’s illness, the commonest sort of dementia.

This doesn’t imply that girls who begin menopause early are powerless towards dementia, Hao stated.

“Dementia might be prevented, and there are a selection of how girls who expertise early menopause could possibly cut back their threat of dementia,” he stated. This consists of getting common train, taking part in leisure and academic actions, not smoking or utilizing alcohol, and sustaining a healthy weight, she stated.

For the research, researchers in contrast age at menopause and dementia prognosis amongst 153,291 girls (common age: 60) who have been a part of the UK Biobank, a big database of genetic and well being info on individuals dwelling in the UK. They appeared for all sorts of dementia, together with Alzheimer’s.

Postmenopausal girls are at larger threat of stroke than pre-menopausal girls, and stroke could trigger vascular dementia, however the research discovered no hyperlink between age at menopause and the chance of this kind of dementia.

Whereas girls who entered menopause early have been at greater threat of dementia, those that entered menopause at age 52 or later had related charges of dementia as girls who began menopause at age 50 or 51, the research confirmed.

The brand new findings held after researchers accounted for different elements that will enhance dementia threat, together with age finally examination, race, training, cigarette and alcohol use, physique fats, coronary heart illness, diabetes, earnings and leisure and bodily actions. The research didn’t embody info on whether or not girls had a family history of dementia or if girls entered menopause early for pure or medical causes, which may have an effect on the findings.

The findings have been introduced Tuesday at a gathering of the American Coronary heart Affiliation held in Chicago and on-line. Analysis introduced at medical conferences is usually thought-about preliminary till printed in a peer-reviewed journal.

These findings are according to different research exhibiting a larger threat of dementia amongst girls with untimely or early menopause, stated Dr. Stephanie Faubion, medical director of the North American Menopause Society and director of the Mayo Clinic Middle for Ladies’s Well being.

“The early lack of estrogen is linked with an elevated threat of a number of antagonistic long-term well being outcomes, and dementia is only one of them,” stated Faubion. Others embody coronary heart illness, brittle bone illness, osteoporosis, temper problems, sexual dysfunction and early demise.

There could also be a job for hormone substitute remedy, she stated.

“Along with suggesting monitoring of those girls, changing estrogen is a key technique and has been proven to mitigate dementia threat (and different dangers) in girls with untimely or early menopause,” Faubion stated.

For years, hormone replacement therapy was extensively prescribed to deal with symptoms of menopause and decrease threat for coronary heart illness, osteoporosis and dementia. This all modified when the landmark Ladies’s Well being Initiative research confirmed that taking estrogen and progestin after menopause could improve girls’s threat for stroke, coronary heart illness, blood clots and breast cancer. (Estrogen helps with menopause signs like hot flashes and vaginal dryness, and progestin is added to guard towards uterine most cancers in girls who nonetheless have a uterus.)

At the moment, hormone replacement therapy could also be prescribed within the lowest dose for the shortest period of time to maximise advantages and reduce potential dangers.

Extra info

The Alzheimer’s Affiliation provides tips about stopping dementia.

 

SOURCES: Wenting Hao, MD, PhD candidate, Shandong College, Jinan, China.; Stephanie Faubion, MD, MBA, director, Middle for Ladies’s Well being, Mayo Clinic, Rochester, Minn., and Jacksonville, Fla., and medical director, North American Menopause Society; March 1, 2022, presentation, American Coronary heart Affiliation assembly, Chicago



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